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World of science

Sirtuins – proteins of longevity

Sirtuins are a family of proteins that play critical roles in regulating cellular health and longevity. They are known for their involvement in epigenetic regulation, meaning they can modify gene...

The FOXO transcription factors and their role in promoting longevity

The FoxO transcription factor family, comprising FoxO1, FoxO3, FoxO4, and FoxO6, is a remarkable group of proteins that receive and integrate various upstream signals to control the transcription of a...

Why glucagon-like peptide-1 (GLP-1) have such a therapeutic potential?

Glucagon-like peptide-1 (GLP-1) was the second incretin to be identified in 1983, with the first identified incretin being gastric inhibitory peptide (GIP), which inhibits the secretion of gastric...